GENE AMPLIFICATIONS
REMBRANDT® MDM2 amplification detection
Technology | FISH | ISH |
| Application | Gene amplification | Gene amplification |
| Area of interest | Formalin-fixed paraffin-embedded tissue sections or fixed cytological specimen | Formalin-fixed paraffin-embedded tissue sections or fixed cytological specimen |
| Region | 12p11.1-q11.1 and 12q15 | 12p11.1-q11.1 and 12q15 |
| Label | ♦ (AF488, 2000) and ♦(AF555, 3000) | Biotin (0100) and Digoxigenin (9900) |
| Product No. | C817K.2030.05 | C817K.0199.05 |
| C817K.2030.10 | C817K.0199.10 | |
| Product Type | Research use only (RUO) or in vitro diagnostic (IVD) | Research use only (RUO) |
| Intended Use | The REMBRANDT® MDM2 amplification FISH detection assay is designed to target the MDM2 gene (12q14.3-15) compared to a CEP12 control probe which allows to detect amplifications of MDM2 and simultaneous enumeration of chromosome 12. | The REMBRANDT® MDM2 amplification ISH detection assay is designed to target the MDM2 gene (12q14.3-15) compared to a CEP12 control probe which allows to detect amplifications of MDM2 and simultaneous enumeration of chromosome 12. |
| Kit contents | C817P.2030 LSI 12q15/CEP12 FISH probe mix | C817P.0199 LSI 12q15/CEP12 ISH probe mix |
| R018R.0000 Pepsin diluent | R025R.0000 PanWash 4 25x SSC | |
| R011R.0000 Pepsin powder | R018R.0000 Pepsin diluent | |
| R025R.0000 PanWash 4 (FISH) 25x SSC | R011R.0000 Pepsin powder | |
| R026R.000 Pre-treatment buffer | R026R.000 Pre-treatment buffer | |
| Z000R.0050 Fluorescent mounting medium |
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All products are also available as stand-alone RUO products